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In distinction, the relationship involving SphK2 and cancer continues to be not well outlined. SphK2 downregulation was simpler than SphK1 downregulation in inhibiting growth of glioblastoma cells 56. Downregulation of SphK2 in MCF7 cells also diminished G2-M arrest and markedly Increased apoptosis induced by doxorubicin, in all probability as a re